Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain (C1C2) Attenuates Deleterious Effects of Pressure Overload
نویسندگان
چکیده
منابع مشابه
Effects of cardiac overexpression of type 6 adenylyl cyclase affects on the response to chronic pressure overload.
Adenylyl cyclase (AC) type 5 (AC5) and AC type 6 (AC6) are the two major AC isoforms in the heart. Cardiac overexpression of AC6 has been shown to be protective in response to several interventions. In this investigation, we examined the effects of chronic pressure overload in AC6 transgenic (TG) mice. In the absence of any stress, AC6 TG mice exhibited enhanced contractile function compared wi...
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AIMS In contrast to the membrane bound adenylyl cyclases, the soluble adenylyl cyclase (sAC) is activated by bicarbonate and divalent ions including calcium. sAC is located in the cytosol, nuclei and mitochondria of several tissues including cardiac muscle. However, its role in cardiac pathology is poorly understood. Here we investigate whether sAC is involved in hypertrophic growth using two d...
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Evodiamine, a traditional Chinese herb Evodia rutaecarpa, has been shown its anti-inflammatory and anti-bacterial properties. However, the role of evodiamine in cardiac hypertrophy and its possible molecular mechanisms remain unclear. Therefore, this study aimed to investigate the effect of evodiamine on cardiac hypertrophy and explore the possible mechanisms. Aortic banding (AB) on mice was pe...
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OBJECTIVES The purpose of this study was to test the hypothesis that cardiac-directed expression of adenylyl cyclase VI (AC(VI)) facilitates atrioventricular (AV) nodal conduction. BACKGROUND Cardiac-directed expression of AC(VI), unlike other strategies to increase cyclic adenosine monophosphate generation, reduces mortality in murine cardiomyopathy. Recent reports suggest that AC(VI) expres...
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BACKGROUND We tested the hypothesis that increased cardiac myocyte adenylyl cyclase (AC) content increases cardiac function and response to catecholamines in cardiomyopathy. METHODS AND RESULTS Transgenic mice with cardiac-directed expression of AC type VI (ACVI) were crossbred with mice with cardiomyopathy induced by cardiac-directed Gq expression. Gq mice had dilated left ventricles, reduce...
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ژورنال
عنوان ژورنال: Human Gene Therapy
سال: 2019
ISSN: 1043-0342,1557-7422
DOI: 10.1089/hum.2018.176